Biosensor interface

A biosensor is a device that measures biological or chemical reactions by generating signals proportional to the concentration of an analyte in the reaction, detected by a sensor. The sensors for the different types of diagnostic needs in this programme will be initially developed by employing established electrochemical biosensor technology in combination with antibody mimetics (artificial peptides or proteins designed to act like antibodies) and fluidic sample handling to minimise handling errors. In parallel, this programme will continue the development of innovative biosensor technology by engineering the molecular components responsible for the binding of proteins used to identify disease (biomarkers). Molecular components have long been engineered to bind biomarkers, but in this programme, we will focus on enhancing the readout generated and combine different readout methods into the molecular components, which will enhance the ability to detect low levels of the biomarkers, reduce interference and improve reliability.

Importantly, this concept is transferable to other biomarkers and will thus provide a general biosensor platform technology for healthcare and other areas.